Scotland will be without fly-half Duncan Weir for the Six Nations due to an arm injury.
The 23-year-old Glasgow Warrior has undergone surgery to repair his right biceps and will be out of action for up to four months.
Weir started every Six Nations match last year, kicking an 80th-minute drop-goal to secure the solitary victory over Italy in Rome.
He won the last of his 18 caps as a replacement against Tonga in November.
Weir was understudy to club-mate Finn Russell during the Autumn internationals, coming off the bench in all three matches.
In September, Wasps and Scotland fly-half Ruaridh Jackson was ruled out for between six and nine months with an anterior cruciate ligament tear.
Glasgow have also announced that loose forward Tyrone Holmes will be out for up to six weeks as he recovers from a fractured eye socket.